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eSpira FM System肺功能檢測系統

eSpira™系統是用于檢測與肺功能相關的全部生理數據的大型系統，可對麻醉動物進行一系列成組實驗的數據自動分析檢測，包括用力肺活量相關數據的測試。廣泛應用于COPD、肺間質疾病、肺纖維化等疾病臨床前研究。

與人肺功能檢測相類似，eSpira™系統提供與人類肺功能指標一致的各種生理指標參數。該系統可用于小鼠、大鼠/豚鼠以及其他大型動物。系統高度自動化并提供豐富的圖標供分析研究使用。

多參數肺功能檢測系統的主要檢測參數：

· 用力呼氣量Forced Expiratory Volume (FEV)

· 肺總量 Total Lung Capacity

· 用力肺活量Forced Vital Capacity

· * 大呼氣流量Peak Expiratory Flow

· * 大呼氣中段流量Maximum Mid Expiratory Flow

· 準靜態壓力容積曲線Quasistatic Pressure Volume Curves

· 功能殘氣量FRC

· 阻力/順應性Resistance/Compliance

· Explanations and more parameters

多參數肺功能檢測系統的產品主要特點：

· 適用于各種實驗動物：小鼠、大鼠、豚鼠、犬、靈長類動物

· 經典的肺量測定法（spirometry）檢測肺功能

· 綜合的肺功能分析

· COPD及肺間質疾病研究的必備工具；

· 在數分鐘內測定FEV(x)、FEF(x)、FVC、FRC、FEVpef、MMEF等參數；

· 氣道阻力和肺順應性直接生理數據檢測；

· 軟件自動生成可直接打印的數據報告。

FM 動物肺功能檢測分析系統 (Anesthetized) --大鼠肺功能測量，小鼠肺功能測量系統：

FM 動物肺功能檢測分析系統提供與人肺功能檢測相同的各種指標參數，例如FEV(x)、FEF(x)、FVC、FRC、MMEF、TLC等用力呼吸相關的生理指標；兼具彌散（DLCO）、Single Breath Nitrogen Washout等功能，廣泛應用于COPD、肺間質疾病、肺纖維化等疾病臨床前研究。

該系統同時也能夠檢測RC系統的阻力與動態肺順應性等全部參數，并能檢測準靜態肺順應性（用于肺塌陷模型的研究）

eSpira FM System肺功能檢測系統/動物肺功能檢測分析系統 (eSpira™ Forced Manoeuvers System)

eSpira FM System for Mouse

Spirometry is the most common method for assessing lung function within the clinical environment， with FEV1 (Forced Expiratory Volume in one second)， in particular， being the most characterised and utilised tests. Until recently， this method of assessing lung function was precluded within the laboratory， as it involved voluntary manoeuvres. However， the EMMS eSpira? system enables a researcher to perform classical spirometry lung function testing on anaesthetised animals.

Typically， animals are intubated or tracheostomised and cannulated. The animal’s lungs are inflated to a set tracheal pressure， and then exposed to a large negative pressure reservoir. This forces the subject to exhale as quickly as possible and enables the scientist to mimic classical clinical spirometry. Parameters calculated include Forced Expiratory Volume (FEVx)， where x is the time in milliseconds， Forced Vital Capacity and maximum mid expiratory flow， which gives an average flow over the middle part of the flow volume curve and is useful for determining mild to moderate airway obstruction.

The graph above illustrates data obtained using the eSpira system in a chronic murine model of asthma. Mice were sensitised with Ovalbumin and challenged on multiple occasions. Control animals were injected with alum only and were administered a saline aerosol. The lung function measurements were performed 24 hours after the last challenge. There was a 49% reduction in Forced Vital Capacity (FVC) and a 46% reduction in Forced Expiratory Volume in 50 milliseconds (FEV50). These data illustrate that the eSpira? system is capable of detecting lung function changes， in a murine asthma model， similar to those observed in the clinical environment.

Parameters Measured Include:

· Forced Expiratory Volume (FEV)

· Total Lung Capacity

· Forced Vital Capacity

· Peak Expiratory Flow

· Maximum Mid Expiratory Flow

· Quasistatic Pressure Volume Curves

· FRC

· Resistance/Compliance

· Explanations and more parameters

Features

· Available for all common species from mouse to primate

· Replicates classical spirometry lung function testing

· Comprehensive lung function analysis

·

Uses

· Acute and Chronic models

· Recovery anaesthesia protocols

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